The HTTP/2 protocol allows a denial of service (server resource consumption) because request cancellation can reset many streams quickly, as exploited in the wild in August through October 2023.
An HTTP Request Forgery issue was discovered in Varnish Cache 5.x and 6.x before 6.0.11, 7.x before 7.1.2, and 7.2.x before 7.2.1. An attacker may introduce characters through HTTP/2 pseudo-headers that are invalid in the context of an HTTP/1 request line, causing the Varnish server to produce invalid HTTP/1 requests to the backend. This could, in turn, be used to exploit vulnerabilities in a server behind the Varnish server. Note: the 6.0.x LTS series (before 6.0.11) is affected.
An issue was discovered in Varnish Cache 7.x before 7.1.2 and 7.2.x before 7.2.1. A request smuggling attack can be performed on Varnish Cache servers by requesting that certain headers are made hop-by-hop, preventing the Varnish Cache servers from forwarding critical headers to the backend.
In Varnish Cache 7.0.0, 7.0.1, 7.0.2, and 7.1.0, it is possible to cause the Varnish Server to assert and automatically restart through forged HTTP/1 backend responses. An attack uses a crafted reason phrase of the backend response status line. This is fixed in 7.0.3 and 7.1.1.